We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Religion is often understood to play a positive role in shaping moral attitudes among believers. We assessed the relationship between church members’ levels of felt connectedness to their respective congregations and perceived similarity in personal and congregational moral values, and whether there was a relationship between these and the amount of time spent in synchronous movement or singing during worship. The similarity between personal and perceived congregational moral importance was correlated with feelings of closeness to one’s congregation but not by (...) the amount of time spent in synchronous movement or singing. Differences in moral foundations scores and in moral importance of specific issues were found between different theological traditions. These findings demonstrate that, for churchgoers, there is a relationship between the use of music or synchronous movement in a church service and feelings of social bonding and there is also a relationship between the degree to which churchgoers identify with their church community and the degree to which they believe their priorities match those of their church. Furthermore, differences in theological tradition appear to be reflected in differences in moral values. (shrink)

Black feminist theory has shown how respectability politics shape cultural discourses about African American women's sexuality. Responding to ‘silent’ depictions resulting from racial uplift strategies among turn-of-the-century middle-class black women, subsequent work theorises alternative discourses that portray a desiring and agentic black female sexual subject. Locating these alternative discourses in a ‘politics of irreverence’, I argue that respectability/irreverence oppositional logic narrowly frames theorising of black female sexuality. Although recent work emphasises dialectical – rather than oppositional – dynamics, this analytic approach (...) is unevenly applied. Binary frameworks continue to shape analyses of women's rap. Drawing upon lyrics of rappers Lil’ Kim and Foxy Brown, I highlight three discursive strategies whereby women rappers render the respectability/irreverence binary problematic: (1) using irreverence to claim respectability, (2) ‘claiming both’ or, embracing contradiction, and (3) beating to the punch. This analysis shows how dialectical approaches account for potential ‘third spaces’ where more complex representational politics are possible. (shrink)

It describes and explains the patient-centered model examining and evaluating qualitative and quantitative research. It comprehensively covers the evolution and the six interactive components of the patient-centered clinical method, taking the reader through the relationships between the patient and doctor and the patient and clinician. All the editors are professors in the Department of Family Medicine at the University of Western Ontario, London, Canada.

Although widely studied in other domains, relatively little is known about the metacognitive processes that monitor and control behaviour during reasoning and decision-making. In this paper, we examined the conditions under which two fluency cues are used to monitor initial reasoning: answer fluency, or the speed with which the initial, intuitive answer is produced, and perceptual fluency, or the ease with which problems can be read. The first two experiments demonstrated that answer fluency reliably predicted Feeling of Rightness judgments to (...) conditional inferences and base rate problems, which subsequently predicted the amount of deliberate processing as measured by thinking time and answer changes; answer fluency also predicted retrospective confidence judgments. Moreover, the effect of answer fluency on reasoning was independent from the effect of perceptual fluency, establishing that these are empirically independent constructs. In five experiments with a variety of reasoning problems similar to those of Alter et al., we found no effect of perceptual fluency on FOR, retrospective confidence or accuracy; however, we did observe that participants spent more time thinking about hard to read stimuli, although this additional time did not result in answer changes. In our final two experiments, we found that perceptual disfluency increased accuracy on the CRT, but only amongst participants of high cognitive ability. As Alter et al.’s samples were gathered from prestigious universities, collectively, the data to this point suggest that perceptual fluency prompts additional processing in general, but this processing may results in higher accuracy only for the most cognitively able. (shrink)

One hundred and three participants solved conflict and non-conflict versions of four reasoning tasks using a two-response procedure: a base rate task, a causal reasoning task, a denominator neglect task, and a categorical syllogisms task. Participants were asked to give their first, intuitive answer, to make a Feeling of Rightness judgment, and then were given as much time as needed to rethink their answer. They also completed a standardized measure of IQ and the actively open-minded thinking questionnaire. The FORs of (...) both high- and low-capacity reasoners were responsive to conflict, such that FORs were lower for conflict relative to non-conflict problems. Consistent with the quantity hypothesis, high-capacity reasoners made a greater distinction between conflict and non-conflict items on measures of Type 2 thinking, namely, rethinking time and probability of changing answers. In contrast to the quality hypothesis, however, this rethinking time did not advantage the ability of the high-capacity group to produce normative answers, except for the base rate task. Indeed, we observed that the correlation between capacity and the probability of normative answers emerged at the initial response, rather than after rethinking. (shrink)

Trust and Governance asks several important questions: Is trust really essential to good governance, or are strong laws more important? What leads people either to trust or to distrust government, and what makes officials decide to be trustworthy? Can too much trust render the public vulnerable to government corruption, and if so what safeguards are necessary? In approaching these questions, the contributors draw upon an abundance of resources to offer different perspectives on the role of trust in government. Enriched by (...) perspectives from political science, sociology, psychology, economics, history, and philosophy, Trust and Governance opens a new dialogue on the role of trust in the vital relationship between citizenry and government. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Overcoming Greed:An Eastern Christian Perspective1Valerie A. KarrasAs an Eastern Orthodox Christian, I have chosen to approach the topic of "overcoming greed" from an Eastern Christian perspective, relying particularly on the writings of some of the early theologians of the Greek East. It is not coincidental either that laissez-faire capitalism arose in the Western Christian world, or that the first strongholds of communism developed in Eastern European, traditionally Orthodox, countries. (...) Both phenomena speak to an intrinsic difference in the way in which human beings are conceived as relating to the world and to each other, both personally and communally.The traditional Eastern Christian model of the human person as not simply caretaker of creation, but fundamentally as a mediator uniting all aspects of creation in humanity's own nature,2 has led historically to a general lack of interest in exploiting creation (in fact, the worst environmental problems in the Orthodox world occurred in countries after they came under totalitarian communist domination). Similarly, the Eastern Orthodox emphasis on the relational, and even communal, nature of salvation created an environment hostile to the individualist, exploitative model upon which modern Western economics has been founded (this has been rapidly changing in post-communist Eastern European countries and Russia, however).The Eastern Church identifies this phenomenon of exploitative and abusive relationships toward nature and other persons as a consequence of the fallen condition of humanity, that is, humanity as it currently exists, in a state where our natural communion with God has been ruptured. In this context, Christianity in general and Eastern Christianity in particular recognize greed as one of the passions (equivalent to what Buddhism describes as "cravings") that are part of our fallen human nature, a consequence of our separation from God. Some of the passions are primarily physical in nature, others emotional or psychic, but in fact virtually all passions are a combination of the two.Greed, a passion of both soul and body that is endemic to our current existence, is typical of this understanding. There are two aspects to the vice of greed: (1) the emotional or spiritual dimension, that is, the acquisitive lust that usually betokens either a deep-seated insecurity or, worse, a desire for power and control; and (2) the [End Page 47] external, physical manifestations of greed in the actual acquisition of things, often to the detriment or exploitation of others. Eastern Christian writings attempt to work on both dimensions of the passion of greed, especially the spiritual, while often distinguishing between greed (a moral vice) and wealth (an amoral condition).This article will focus on two early church theologians, Clement of Alexandria and John Chrysostom. In particular, it will focus on their biblical exegeses of two pertinent New Testament passages: Jesus' conversation with a young righteous scholar of the Mosaic Law and the parable of Lazarus and the rich man, respectively. Finally, I will suggest that, for Orthodox Christians, an important key to overcoming greed is disciplined asceticism, to be practiced by all persons and not simply by monks and nuns. Asceticism—the exercise of control over the passions through fasting, prayer, chastity (understood differently for married and unmarried persons), and almsgiving—is the vehicle by which to cultivate an attitude of apatheia or passionlessness, the Christian equivalent of the Buddhist ideal of detachment.Clement was a philosopher-theologian who headed the great Christian catechetical school in Alexandria in the late second century C.E. In his treatise Who IstheRich ManWhoWill Be Saved? 3 Clement mused on the spiritual and soteriological dimensions of greed by reflecting on Jesus' encounter with the wealthy young "lawyer," that is, scholar of the Mosaic Law, who questioned Jesus on how to acquire eternal life. In his response, the young man showed himself righteous in his adherence to the demands of the law, but ultimately unwilling to commit all of himself by giving away his property, even though Jesus said that it was the price to inherit eternal life.Clement pondered whether it were therefore possible for anyone wealthy to be saved, given Jesus' declaration that "it is easier for a camel to go through the eye of a needle than for a rich man... (shrink)

The impact of "human enhancement" can manifest itself only overtime. And this is why, the author argues, "human enhancement" is an issue for the youth-oriented policies. As such, the problem of "human enhancement" is a social problem. The author stresses the influence of individual experiments that young people run on themselves and that have to do with human enhancement. He argues that these experiments have the potential of opening new directions for a social construction of reality. He relates this potential (...) to the innovative impulse that young people have. (shrink)

We tested the hypothesis that choices determined by Type 1 processes are compelling because they are fluent, and for this reason they are less subject to analytic thinking than other answers. A total of 104 participants completed a modified version of Wason's selection task wherein they made decisions about one card at a time using a two-response paradigm. In this paradigm participants gave a fast, intuitive response, rated their feeling of rightness for that response, and were then allowed free time (...) to reconsider their answers. As we predicted, answers consistent with a matching heuristic were made more quickly than other answers, were given higher FOR ratings, and received less subsequent analysis as measured by rethinking time and the probability of changing answers. These data suggest that reasoning biases may be compelling because they are fluently generated; this is turn creates a strong FOR, which acts as a signal that further analysis is not necessary. (shrink)

China’s extensive media presence in Africa aims to distinguish itself through the use of constructive journalism in contrast with the perceived dominance of conflict journalism by Western media outlets. However, many scholars have raised questions of consistency surrounding Chinese media’s use of constructive journalism in representing Africa (e.g. Marsh, Citation2016). With perspectives from Galtung’s (Citation1987, p. 1998) conflict and peace journalism, this research applies Critical Discourse Analysis to examine Chinese media’s representation of Africa to an international audience. Using linguistic data (...) from China Radio International’s Today, it challenges the distinctions among peace journalism, solutions journalism and constructive journalism. The findings show that China’s claim of constructive journalism strongly favors the coverage of China, yet is largely absent in the coverage of the African continent. It suggests that while Chinese state-sponsored media utilizes the so-called constructive journalism when presenting information about a specific region to that region, these representations are not consistent across their international coverage. Hence, Africa remains a victim of conflict journalism. (shrink)

Suddendorf & Corballis (S&C) argue that episodic memory is the most flexible and recently evolved memory system, and point to the reorganization of prefrontal cortex throughout human evolution as the neuroanatomical substrate. Their approach, however, fails to address the unique role that the hippocampus, a primitive brain region, plays in creating and recalling episodic memories, as well as future event construction.

This book-length essay introduces and discusses main theoretical positions the author uses in his study of Russian literature of the 19th and 20th centuries. It offers new original approaches, in particular the systematic analysis of anthropological foundations that determine how the idea of the Work is being formed. The author focuses on the specific literary tradition going from Nikolai Gogol, Fyodor Dostoevsky, and Andrei Bely to Andrey Platonov and Oberiu, the group represented by such names as Alexander Vvedensky, Daniil Kharms, (...) Yakov Druskin, Leonid Lipavsky, and Konstantin Vaginov. (shrink)

Согласно тем истолкованиям Достоевского, которые предложены Бахтиным, голос предполагает диалог и тем самым участие сознания, а также смысла; этим путем мы приходим к личности. Однако эта интерпретация оставляет в стороне - уже у самого Достоевского - другие существенные моменты: например, спонтанныешумы и особенно слушание. Следовало бы также более внимательно исследовать отношения между диалогом и встречей. Selon Bakhtine interprétant Dostoïevski, la voix implique le dialogue et par là l’intervention de la conscience, et aussi le sens ; on arrive ainsi à la (...) personne. Mais cette interprétation laisse de côté, même chez Dostoïevski, d’autres moments essentiels : par exemple les bruits spontanés et surtout l'écoute. Il faudrait en outre faire une analyse plus juste des rapports du dialogue et de la rencontre. According to Bakhtin interpreting Dostoyevsky, voice implies dialogue and hence the intervention of consciousness , and also meaning; therefore, we are led to consider the person. But this interpretation overlooks, even in Dostoyevsky, other key moments: for instance, spontaneous noises, and especially listening. A more accurate analysis should be made of the relationships between dialogue and encounter. (shrink)

Using normative correctness as a diagnostic tool reduces the outcome of complex cognitive functions to a binary classification (normative or non-normative). It also focuses attention on outcomes, rather than processes, impeding the development of good cognitive theories. Given that both normative and non-normative responses may be produced by the same process, normativity is a poor indicator of underlying processes.

Tomasello et al. have not characterized the motivation underlying shared intentionality, and we hope to encourage research on this topic by offering comparative paradigms and specific empirical questions. Although we agree that nonhuman primates differ greatly from us in terms of shared intentionality, we caution against concluding that they lack all aspects of it before other empirical tools have been exhausted. In addition, identifying the conditions in which humans spontaneously engage in shared intentionality, and the conditions in which we fail, (...) will more fully characterize this ability. (shrink)

In this reply, we provide an analysis of Alter et al. response to our earlier paper. In that paper, we reported difficulty in replicating Alter, Oppenheimer, Epley, and Eyre’s main finding, namely that a sense of disfluency produced by making stimuli difficult to perceive, increased accuracy on a variety of reasoning tasks. Alter, Oppenheimer, and Epley argue that we misunderstood the meaning of accuracy on these tasks, a claim that we reject. We argue and provide evidence that the tasks were (...) not too difficult for our populations and point out that in many cases performance on our tasks was well above chance or on a par with Alter et al.’s participants. Finally, we reiterate our claim that the distinction between answer fluency and perceptual fluency is genuine, and argue that Thompson et al. provided evidence that these are distinct factors that have different downstream effects on cognitive processes. (shrink)

In this paper I identify and explore resonances between a contemporary dance piece – Jonathan Burrowss and Matteo Fargions Both Sitting Duet (2003) – and some theories from Gilles Deleuzes Difference and Repetition (1994). The duet consists of rhythmic, repetitive patterns of mainly hand movements performed by two men, for the most part, sitting on chairs. My argument, with Deleuze, is that the repetitions in the dance are productive rather than reductive. They are never repetitions of the same. The ways (...) in which the hand patterns are played with constitute the multiple differences and repetitions we witness. I discuss these in relation to Deleuzes theories of repetition, specifically the ways in which repetition differs from resemblance avoiding the limitations of notions of origin and representation. I argue that, because of these differences which are bound up in the affective qualities of the duet that characterise the distinctive relationship between the two performers, the work, like Deleuzes theories, is transgressive with potential for change. I demonstrate this through its resonances with Deleuzes notions of simulacra and importantly his discussion of the Other. In the process, I aim to show how dance and philosophy can open up something of each other and, in this instance, suggest ways of thinking encounters otherwise. My aim is to foreground the transgressive potential of the extended repetition of the dance for making differences that matter between self and other. (shrink)

What constitutes an adequate basis for feminist consciousness? What values and concerns are feminists to bring to bear in challenging present standards of well-being and articulating alternative visions of collective life? This essay takes a close and critical look at these questions as they are addressed in the work of political theorist Jean Elshtain. An outspoken defender of "pro-family feminism," Elshtain has urged contemporary feminists to reclaim the "female subject" within the private sphere. Enormous problems attend Elshtain's counsel and these (...) have as much to do with the political implications of her argument as with her reading of the Sophoclean tragedy Antigone. With an eye towards foregrounding what some of these problems are, this essay elaborates an alternative reading of Sophocles' Antigone and moves from that exposition to an examination of why it is that Elshtain's claims and conclusions are politically unsound and unsustainable. (shrink)

Non-communicable diseases are no longer largely limited to high-income countries and the elderly. The burden of non-communicable diseases is rising across all country income categories, in part because these diseases have been relatively overlooked on the global health agenda. Historically, communicable diseases have been prioritized in many countries as they were perceived to constitute the greatest disease burden, especially among vulnerable and poor populations, and strategies for prevention and treatment, which had been successful in high-income settings, were considered feasible and (...) often affordable in low-income settings. This prioritization has reduced the communicable diseases burden globally but has left non-communicable diseases largely neglected. A new approach is urgently needed to tackle non-communicable diseases. Based on an analysis of potential features which may have underlain the different approaches to non-communicable diseases and communicable diseases until now, including acuity of disease, potential for control or cure, cost, infectiousness, blaming of individuals and logistical barriers, little ethical or rational justification can be found to support continued neglect of non-communicable diseases. Justice demands access to quality and affordable care for all. An equitable approach to non-communicable diseases is therefore strongly mandated on medical, ethical, economic, and public health grounds. Funding must not however be diverted away from communicable diseases, which continue to require attention—but concomitantly, funding for non-communicable diseases must be increased. International and multi-sectoral action is required to accelerate progress towards true universal health coverage and towards achievement of all of the sustainable development goals, such that prevention and access to care for non-communicable disease can become a global reality. (shrink)

Ubiquitous healthcare is an emerging area of technology that uses a large number of environmental and patient sensors and actuators to monitor and improve patients' physical and mental condition. Tiny sensors gather data on almost any physiological characteristic that can be used to diagnose health problems. This technology faces some challenging ethical questions, ranging from the small-scale individual issues of trust and efficacy to the societal issues of health and longevity gaps related to economic status. It presents particular problems in (...) combining developing computer/information/media ethics with established medical ethics. This article describes a practice-based ethics approach, considering in particular the areas of privacy, agency, equity and liability. It raises questions that ubiquitous healthcare will force practitioners to face as they develop ubiquitous healthcare systems. Medicine is a controlled profession whose practise is commonly restricted by government-appointed authorities, whereas computer software and hardware development is notoriously lacking in such regimes. (shrink)

In two experiments, we investigated how people interpret and reason with realistic conditionals in the form of inducements (i.e., promises and threats) and advice (i.e., tips and warnings). We found that inducements and advice differed with respect to the degree to which the speaker was perceived to have (a) control over the consequent, (b) a stake in the outcome, and (c) an obligation to ensure that the outcome occurs. Inducements and advice also differed with respect to perceived sufficiency and necessity, (...) as well as the degree to which these statements were perceived to be effective in changing the behaviour described in the antecedent of the conditional. Multiple regression analyses indicated that perceived control over the consequent, necessity, and sufficiency emerged as the best predictors of (a) the degree to which statements were perceived to be effective in changing the behaviour of the addressee, and (b) inference patterns on a conditional arguments task. (shrink)

Recent research (e.g., Evans & Over, 2004) has provided support for the hypothesis that people evaluate the probability of conditional statements of the form if p then q as the conditional probability of q given p , P( q / p ). The present paper extends this approach to pragmatic conditionals in the form of inducements (i.e., promises and threats) and advice (i.e., tips and warnings). In so doing, we demonstrate a distinction between the truth status of these conditionals and (...) their effectiveness as speech acts. Specifically, while probability judgements of the truth of conditional inducements and advice are highly correlated with estimates of P( q / p ), their perceived effectiveness in changing behaviour instead varies as a function of the conditional probability of q given not-p , P( q / ∼p ). Finally, we show that the conditional probability approach can be extended to predicting inference rates on a conditional reasoning task. (shrink)

When do humans become moral beings? This commentary draws on developmental psychology theory to expand the understanding of early moral behaviours. We argue that by looking at a broader range of other-oriented acts than what has been considered by Baumard et al., we can find support for the mutualistic approach to morality even in early instances of other-oriented behaviours.

Recipient of Choice Magazine's 1996 Outstanding Academic Book Award Author Raymond Morrow outlines and recounts the development of the major tenets of critical theory, exemplifying them through the works of two of their most influential, recent adherents: Jürgen Habermas and Anthony Giddens. Beginning with a comprehensive yet meticulous explication of critical theory and its history, the author next discusses it within the context of a research program; his work concludes with an examination of empirical methods. Emphasizing the connections between critical (...) theory, empirical research, and social science methodology, Morrow's volume offers refreshing insights on traditional and current material. (shrink)

The shortage of organs for transplantation by its nature prompts ethical dilemmas. For example, although there is an imperative to save human life and reduce suffering by maximising the supply of vital organs, there is an equally important obligation to ensure that the process by which we increase the supply respects the rights of all stakeholders. In a relatively unexamined practice in the USA, organs are procured from unrepresented decedents without their express consent. Unrepresented decedents have no known healthcare wishes (...) or advance care planning document; they also lack a surrogate. The Revised Uniform Anatomical Gift Act of 2006 sends a mixed message about the procurement of organs from this patient population and there are hospitals that authorise donation. In addition, in adopting the RUAGA, some states included provisions that clearly allow organ procurement from unrepresented decedents. An important unanswered question is whether this practice meets the canons of ethical permissibility. The current Brief Report presents two principled approaches to the topic as a way of highlighting some of the complexities involved. Concluding remarks offer suggestions for future research and discussion. (shrink)

We propose, following Clark, that generative models also play a central role in the perception and interpretation of linguistic signals. The data explanation approach provides a rationale for the role of prediction in language processing and unifies a number of phenomena, including multiple-cue integration, adaptation effects, and cortical responses to violations of linguistic expectations.

De Neys proposed a “switch” model to address what he argued to be lacuna in dual-process theory, in which he theorized about the processes that initiate and terminate analytic thinking. We will argue that the author neglected to acknowledge the abundant literature on metacognitive functions, specifically, the meta-reasoning framework developed by Ackerman and Thompson (2017), that addresses just those questions.

Past research suggests that death pushes some individuals to strongly promote religious worldviews. The current work explores the role of conceptual metaphor in this process. Past research shows that metaphors can provide meaning and certainty, suggesting that death may therefore cause people to be more attracted to epistemically beneficial metaphoric descriptions of God. In three studies, we test this possibility against competing alternatives suggesting that death concerns may cause more selective metaphor preferences. Using both correlational and experimental methods, we find (...) that death concern is generally associated with embracing metaphors about God. (shrink)

Three experiments investigated reasoners' beliefs about causal powers; that is, their beliefs about the capacity of a putative cause to produce a given effect. Covariation-based theories (e.g., Cheng, 1997; Kelley, 1973; Novick & Cheng, 2004) posit that beliefs in causal power are represented in terms of the degree of covariation between the cause and its effect; covariation is defined in terms of the degree to which the effect occurs in the presence of the cause, and fails tooccur in the absence (...) of the cause. To test the degree to which beliefs incausal power are reflected in beliefs about covariation information, participants in three experiments rated their beliefs that putative causes have the capacity to produce a given effect (i.e., possess the causal power to produce an effect) as well as their beliefs regarding the degree to which the putative cause and effectcovary. A strong positive correlation was discovered between participants' beliefs in causal power and their beliefs that the effect occurs in the presence of the cause. However, no direct relationship was found between participants' beliefs in causal power and their belief that the effect will fail tooccur in the absence of the cause. These findings were replicated using bothwithin- (Experiments 1 and 3) and between-subject designs (Experiment 2). In Experiment 3, we extended these analyses to measures of familiarity, imageability, and detailedness of the representation. We found that participants' beliefs in causal power were strongly associated with familiarity, and imageability, but not the perceived detailedness of the cause and effect relationship. These data provide support for a multidimensional account of causal knowledge whereby people's representations of causation include, but are not limited to, the covariation, familiarity, and imageability of cause and effect relationships. (shrink)